Sulfadoxine-Pyrimethamine for the Treatment of Acute Malaria in Children in Papua New Guinea
- 1 January 1982
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 31 (1), 1-9
- https://doi.org/10.4269/ajtmh.1982.31.1
Abstract
Chloroquine-resistant Plasmodium falciparum malaria is increasing in prevelance in Papua New Guinea and alternative therapies for acute malaria are being sought. A trial of sulfadoxine-pyrimethamine for the treatment of acute falciparum malaria in children has been carried out in Madang, Papua New Guinea. Eighty-five children were treated with sulfadoxine-pyrimethamine, either alone or in combination with a single 10 mg/kg dose of chloroquine. Of 78 children completing 28-days follow-up, treatment failures occurred in 15 (19.2%) and of these, 8 (10.3%), are believed to be sulfadoxine-pyrimethamine resistant; the others remain equivocal. There was no advantage in this study in combining a single dose of chloroquine with sulfadoxine-pyrimethamine; indeed, this combination was associated with an increased incidence of vomiting. It is argued that sulfadoxine-pyrimethamine should not become the standard presumptive treatment for acute malaria in Papua New Guinea.This publication has 8 references indexed in Scilit:
- SINGLE-DOSE THERAPY OF FALCIPARUM-MALARIA WITH MEFLOQUINE OR PYRIMETHAMINE-SULFADOXINE1979
- Quantitative Aspects of Pyrimethamine-Sulfonamide SynergismThe American Journal of Tropical Medicine and Hygiene, 1977
- Host Failure in Treatment of Malaria with Sulfalene and PyrimethamineAnnals of Internal Medicine, 1975
- ANTIMALARIAL EFFECTS OF SULPHORMETHOXINE DIAPHENYLSULPHONE AND SEPARATE COMBINATIONS OF THESE WITH PYRIMETHAMINE - A REVIEW OF PRELIMINARY INVESTIGATIONS CARRIED OUT IN TANZANIA1968
- SULPHORMETHOXINE IN CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN THAILANDThe Lancet, 1967
- Ranking Procedures for Arbitrarily Restricted ObservationBiometrics, 1967
- Antimalarial Activity of Sulphonamides and a Sulphone, Singly and in Combination with Pyrimethamine, against Drug Resistant and Normal Strains of Laboratory PlasmodiaNature, 1966
- The Evaluation of Sulfonamides, Alone or in Combination with Pyrimethamine, in the Treatment of Multi-Resistant Falciparum MalariaThe American Journal of Tropical Medicine and Hygiene, 1966