RENAL FUNCTION IN ANOREXIA NERVOSA

Abstract

Renal function was examined in 8 girls and 4 boys with anorexia nervosa (AN) ranging in age from 12.6-18.2 yr. The weight loss at the time of the study averaged 26%. Glomerular filtration rate (GFR), PAH [p-aminohippurate] clearance (CPAH) and urinary concentrating capacity were determined in the patients and in 5 controls. Both GFR and CPAH were generally reduced in AN. The reduction of GFR was out of proportion to the reduction of CPAH as shown by a significantly lower filtration fraction (FF) in AN. The low FF could be attributed to reduced water permeability of the glomerular capillary. The urinary concentrating capacity following fluid deprivation was moderately depressed both before and after the administration of vasopressin. The concentrating defect in AN was apparently of renal origin.