Perfusion Studies of the Human Placenta. I. Effect of Estradiol and Human Chorionic Gonadotropin on Citric Acid Metabolism12
Open Access
- 1 November 1958
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 37 (11), 1516-1523
- https://doi.org/10.1172/jci103743
Abstract
When human chorionic gonadotropin (HCG) plus estradiol-17B were added to the perfusion fluid citrate utilization was enhanced after a 5-hour lag period. The addition of HCG alone appeared to stimulate citrate utilization to a lesser degree and after a longer lag period. Estradiol alone had no effect. Citrate utilization was inhibited by the addition of fluoroacetate and the response to hormonal stimulation completely blocked.Keywords
This publication has 21 references indexed in Scilit:
- ACTIVATION OF HYDROGEN TRANSFER BETWEEN PYRIDINE NUCLEOTIDES BY STEROID HORMONESProceedings of the National Academy of Sciences, 1958
- EFFECT OF HUMAN CHORIONIC GONADOTROPIN ON THE SECRETION OF TESTOSTERONE AND 4-ANDROSTENE-3,17-DIONE BY THE CANINE TESTIS1Endocrinology, 1957
- THE INTERCONVERSION OF ESTRONE AND ESTRADIOLIN THE PERFUSED HUMAN PLACENTA12Endocrinology, 1956
- THE CONCENTRATION OF RELAXIN IN THE BLOOD SERUM AND OTHER TISSUES OF WOMEN DURING PREGNANCY*Journal of Clinical Endocrinology & Metabolism, 1955
- ADRENOCORTICOTROPHIC ACTIVITY OF PLACENTAL EXTRACTSBJOG: An International Journal of Obstetrics and Gynaecology, 1953
- Biochemistry of fluoroacetate poisoning. The isolation and some properties of the fluorotricarboxylic acid inhibitor of citrate metabolismProceedings of the Royal Society of London. B. Biological Sciences, 1953
- Extraction of Adrenal Cortex Hormone Activity from Placental TissueScience, 1952
- Adrenal Cortical Hormones in Human PlacentaNature, 1952
- Hormone secretion by human placenta grown in the eyes of rabbitsAmerican Journal of Obstetrics and Gynecology, 1951
- SIMULATED ADRENO-CORTICAL ACTIVITY DURING PREGNANCY IN AN ADDISONIAN PATIENT 1JCI Insight, 1950