Photoacoustic flow measurements by use of laser-induced shape transitions of gold nanorods
- 15 December 2005
- journal article
- Published by Optica Publishing Group in Optics Letters
- Vol. 30 (24), 3341-3343
- https://doi.org/10.1364/ol.30.003341
Abstract
A quantitative technique for flow measurements based on a wash-in analysis is proposed. The technique makes use of the shape dependence of the optical absorption of gold nanorods and the transitions in their shape induced by pulsed laser irradiation. The photon-induced shape transition of gold nanorods involves mainly a rod-to-sphere conversion and a shift in the peak optical absorption wavelength. The application of a series of laser pulses will induce shape changes in gold nanorods as they flow through a region of interest, with quantitative flow information being derived from the photoacoustic signals from the irradiated gold nanorods measured as a function of time. To demonstrate the feasibility of the technique, a Nd:YAG laser operating at 1064 nm was used for irradiation and a 1 MHz ultrasonic transducer was used for acoustic detection. The flow velocity ranged from 0.35 to . Excellent agreement between the measured velocities and the actual velocities was demonstrated, with a linear regression correlation coefficient of 0.93. This study is a pioneer work on wash-in flow estimation in photoacoustic imaging.
Keywords
This publication has 8 references indexed in Scilit:
- Time-intensity based optoacoustic flow measurements with gold nanoparticlesPublished by SPIE-Intl Soc Optical Eng ,2005
- Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomographyMolecular Imaging & Biology, 2004
- Quantitative analysis of multivalent interactions of carbohydrate-encapsulated gold nanoparticles with concanavalin AElectronic supplementary information (ESI) available: detailed experimental procedures, SPR response curves and compound characterization data. See http://www.rsc.org/suppdata/cc/b3/b308995a/Chemical Communications, 2003
- Time-intensity-based volumetric flow measurements: an in vitro studyJapanese Journal of Clinical Oncology, 2002
- Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials ScienceAngewandte Chemie International Edition, 2001
- Shape and size dependence of radiative, non-radiative and photothermal properties of gold nanocrystalsInternational Reviews in Physical Chemistry, 2000
- In vitro flow quantification with contrast power Doppler imagingJapanese Journal of Clinical Oncology, 2000
- The Shape Transition of Gold NanorodsLangmuir, 1998