THE EFFECT OF INSULIN ON THE URINARY EXCRETION OF SODIUM, CHLORIDE, NITROGEN AND GLUCOSE IN NORMAL RATS

Abstract

The tolerance of normal, forcefed [male] rats to regular insulin and to protamine zinc insulin was studied. Small doses of insulin did not produce any changes from normal. States of insulin hypoglycemia and shock were associated with inhibition of growth or a definite wt. loss, an increased Na and Cl loss which was followed by compensatory retention, an increased excretion of NPN and an occasional excretion of small amts. of glucose in the urine. Following the withdrawal of large doses of insulin there was a temporary period of hyperglycemia and in one rat glycosuria appeared.