Effects of γ-Aminobutyric Acid and Histamine on Prolactin Secretion in the Rat

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Abstract
Histamine releases prolactin (PRL) in estrogen-progesterone primed male rats after both iv and intracisternal (ic) injection, but does not affect in vitro PRL secretion. This stimulatory effect is reversed by the a-adrenergic antagonist phenoxybenzamine and the histamine antagonist diphenhydramine. γ-Amino butyric acid (GABA), which has little in vivo effect of its own, interferes with the activity of histamine and a variety of other stimulators of PRL secretion. These results suggest the involvement of the naturally-occurring substances histamine and GABA in the central regulation of PRL secretion.