ACUTE AND CHRONIC EFFECTS OF NALTREXONE AND NALOXONE ON SCHEDULE-CONTROLLED BEHAVIOR OF SQUIRREL-MONKEYS AND PIGEONS
- 1 January 1981
- journal article
- research article
- Vol. 216 (3), 500-509
Abstract
Dose-effect curves were obtained for the influence of naltrexone, of naloxone and of morphine on lever-pressing responses of squirrel monkeys and key-pecking responses of pigeons maintained by food presentation during fixed-interval (FI) and fixed-ratio (FR) components of a multiple schedule. Morphine caused dose-related decreases in FI and FR responding, with complete suppression occurring after 3 mg/kg was administered to monkeys and after 10 mg/kg was administered to pigeons. Naltrexone doses as low as 0.03 mg/kg (monkeys) or 0.1 mg/kg (pigeons) and naloxone doses as low as 0.1 mg/kg (monkeys) or 1 mg/kg (pigeons) shifted morphine dose-effect curves by one or more log units to the right. The effects of a 3 mg/kg injection of morphine were completely blocked by naltrexone (0.1-0.3 mg/kg) injected more than 2 h before morphine. Naltrexone was 3-10 times more potent than naloxone as an antagonist of morphine was longer acting. Given alone, only high doses of naltrexone or naloxone (10 mg/kg, monkeys; 56 mg/kg, pigeons) had pronounced actions; FR and Fl responding were markedly decreased and vomiting often occurred. Repeated daily injections of these high doses of naltrexone or naloxone resulted in little or no tolerance. After termination of chronic treatment 1-6 mo., dose-effect curves for naltrexone on FR and FI responding maintained by food presentation were shifted markedly to the left with the monkeys, but not with the pigeons.This publication has 9 references indexed in Scilit:
- Effects of repeated injections of naltrexone on antagonism of rate decreases by morphine in the pigeonPharmacology Biochemistry and Behavior, 1978
- Hyperalgesia Induced by Naloxone Follows Diurnal Rhythm in Responsivity to Painful StimuliScience, 1977
- EFFECTS OF MORPHINE, METHADONE, NALORPHINE AND NALOXONE ON RESPONDING UNDER SCHEDULES OF ELECTRIC-SHOCK TITRATION1977
- ELECTRIC-SHOCK TITRATION - EFFECTS OF MORPHINE, METHADONE, PENTAZOCINE, NALORPHINE, NALOXONE, DIAZEPAM AND AMPHETAMINE1977
- MORPHINE, PENTAZOCINE AND NALOXONE EFFECTS ON RESPONDING UNDER A MULTIPLE SCHEDULE OF REINFORCEMENT IN RHESUS-MONKEYS AND PIGEONS1976
- SOME BEHAVIORAL-EFFECTS OF MORPHINE, NALOXONE AND NALORPHINE IN SQUIRREL-MONKEY AND PIGEON1976
- EFFECTS OF MORPHINE AND NARCOTIC-ANTAGONISTS ON AVOIDANCE-BEHAVIOR OF SQUIRREL-MONKEY1976
- Effects of morphine alone and in combination with naloxone or d-amphetamine on shock-maintained behavior in the squirrel monkeyPsychopharmacology, 1976
- CONDITIONED SUPPRESSION BY A STIMULUS ASSOCIATED WITH NALORPHINE IN MORPHINE‐DEPENDENT MONKEYS1Journal of the Experimental Analysis of Behavior, 1967