Repair and Processing Events at DNA Ends
- 28 September 2007
- book chapter
- Published by Wiley
- Vol. 211, 198-208
- https://doi.org/10.1002/9780470515433.ch13
Abstract
Cell nuclei contain several abundant enzymes that bind rapidly and avidly to exposed termini of DNA. The properties and physiological roles of such factors are described; they include poly (ADP-ribose) polymerase, DNA-dependent protein kinase, several DNA ligases and excision-repair enzymes. Telomeres normally seem shielded from these activities by telomere-binding proteins. If incomplete protection of telomeres occurred, the functions of the DNA end-specific enzymes would be relevant for processing of telomeres. This could include alternative pathways for telomere propagation in telomerase-negative cells.Keywords
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