Free Amino Acids in Plasma and Tissues of Rats Fed a Vitamin B6-deficient Diet

Abstract

Amino acids were determined in plasma, muscle and liver tissue of rats receiving vitamin B₆-deficient or control diets. In the vitamin B₆-deficient animals, there was a pronounced increase in the glycine-to-serine ratio, an increase in cystathionine, and an increase in aspartic acid accompanied by a decrease in alanine. The changes in plasma amino acids were accentuated by a dietary supplement of glycine.