Basic antiinflammatory compounds. N,N',N''-Trisubstituted guanidines
- 1 January 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (1), 13-20
- https://doi.org/10.1021/jm00175a004
Abstract
A variety of basic N,N'',N"-trisubstituted guanidines was prepared and tested for antiinflammatory activity. Compounds with a thiazolylguanidine moiety linked to the 4 position of the 2-methylquinoline ring exhibited fairly high antiinflammatory activity. Optimal activity was associated with the presence of N-cycloalkyl substituents on N"-4-(2-methylquinolyl)-N''-2-thiazolylguanidine. Pharmacological data [mice, rat and bovine] on N-cyclohexyl-N"-4-(2-methylquinolyl)-N''-2-thiazolylguanidine (SR 1368) are presented and discussed.This publication has 6 references indexed in Scilit:
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