Role of porin proteins OmpF and OmpC in the permeation of beta-lactams
- 1 December 1982
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 22 (6), 942-948
- https://doi.org/10.1128/aac.22.6.942
Abstract
Mutants of Escherichia coli K-12 lacking major outer membrane proteins were obtained by selecting for resistance to the .beta.-lactam cefoxitin. Three classes of resistant strains were found: mutants in ompB, a regulatory locus for proteins OmpF and OmpC; mutants in ompF; and 1 mutant in tpo. The OmpF and OmpC proteins facilitate penetration of .beta.-lactams through the outer membrane.This publication has 35 references indexed in Scilit:
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