Thermal Stability of Mefruside–Polyvinylpyrrolidone Solid Dispersions
- 31 December 1985
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 03 (1), 41-44
- https://doi.org/10.1023/a:1016320831469
Abstract
The stability of mefruside–polyvinylpyrrolidone (PVP) 30 solid dispersions at ratios of mefruside/PVP 30 of 9/1, 7/3, and 5/5 (g/g) after mechanical (tableting) and allothermic stressing (50, 60, and 70°C up to 240 hr) was investigated. Only the 5/5 (g/g) solid dispersion showed no recrystallization of mefruside, whereas a slight increase in crystallinity in the 7/3 (g/g) solid dispersion and a strong increase in the 9/1 (g/g) product were detected. The mechanisms of drug recrystallization in such “high-energy products” are discussed.This publication has 3 references indexed in Scilit:
- [Correlations between macromolecular adjuvants and drugs].1973
- Pharmaceutical Applications of Solid Dispersion SystemsJournal of Pharmaceutical Sciences, 1971
- Possible Complex Formation BetweenMacromolecules and Certain Pharmaceuticals X* The Interaction of Some Phenolic Compounds with Polyethylene Glycols, Polypropylene Glycols, and PolyvinylpyrrolidoneJournal of the American Pharmaceutical Association (Scientific ed.), 1956