Tumor targeting carboxylesterase fused with anti-CEA scFv improve the anticancer effect with a less toxic dose of irinotecan
Open Access
- 21 December 2007
- journal article
- research article
- Published by Springer Nature in Cancer Gene Therapy
- Vol. 15 (2), 94-100
- https://doi.org/10.1038/sj.cgt.7701100
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Irinotecan plus Cisplatin Compared with Etoposide plus Cisplatin for Extensive Small-Cell Lung CancerNew England Journal of Medicine, 2002
- The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissuesSeminars in Cancer Biology, 1999
- Targeting enzymes for cancer therapy: old enzymes in new rolesBritish Journal of Cancer, 1994
- Synergistic Enhancement of Cisplatin Cytotoxicity by SN-38, an Active Metabolite of CPT-11, for Cisplatin-resistant HeLa CellsJapanese Journal of Cancer Research, 1994
- Comparison of Topoisomerase I Inhibition, DNA Damage, and Cytotoxicity of Camptothecin Derivatives Presently in Clinical TrialsJNCI Journal of the National Cancer Institute, 1994
- Metabolic Activation of CPT-11, 7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin, a Novel Antitumor Agent, by Carboxylesterase.Biological & Pharmaceutical Bulletin, 1994
- Biochemical Characterization of 25 Distinct Carcinoembryonic Antigen (CEA) Epitopes Recognized by 57 Monoclonal Antibodies and Categorized into Seven Groups in Terms of Domain Structure of the CEA MoleculeHybridoma, 1992
- Antibody directed enzymes revive anti-cancer prodrugs conceptBritish Journal of Cancer, 1987
- The use of avidin-biotin interaction in immunoenzymatic techniques.Journal of Histochemistry & Cytochemistry, 1979
- Use of Radiolabeled Antibodies to Carcinoembryonic Antigen for the Detection and Localization of Diverse Cancers by External PhotoscanningNew England Journal of Medicine, 1978