LIPOGENESIS AND CO2FORMATION FROM ACETATE IN THE LIVER OF THE HYPOPHYSECTOMIZED RAT1

Abstract

Incorporation of the C14 of added acetate-1-C14 to fatty acids and CO2 was compared in liver slices prepared from normal and hypophysectomized rats fed, ad libitum, an adequate diet. Livers of hypophysectomized rats lost, to a considerable extent, the capacity to convert acetate carbon to fatty acids. This loss was observed as early as 14 hours and as late as 175 days after hypophysectomy. No appreciable difference in the recoveries of C14O2, was observed in the experiments with livers of normal and hypophysectomized rats.