Over a hundred years has elapsed since carcinoma of the pancreas was first described as a clinical entity. In this period a considerable number of data have been accumulated relative to the course of the disease. However, as yet one is only rarely able to recognize it in its early phase. Furthermore, little progress has been made in the therapy of the condition; thus, carcinoma of the pancreas at present is one of the more discouraging medical problems. With the renewed interest in the cancer problem as a whole, the less common tumors become important problems for reconsideration. It is for this reason that we present this paper, in which we briefly review the development of the present knowledge of the disease; report on a series of patients, dealing in particular with the clinical course and the morbid anatomy as revealed at operation and autopsy, comparing our experiences with those