Mitochondrial factors in the utilization of sugars inSaccharomyces cerevisiae

Abstract

SUMMARY: Cytoplasmic petite mutants, spontaneous and induced, show various patterns of ability υ. inability to utilize the sugars galactose, α-methylglucoside and maltose, depending on the strain from which they were isolated. Petites recombine and segregate their different sugar deficiencies among vegetative diploid progeny when crossed, indicating mitochondrial control. Crosses between petites and wild-type further indicate that mitochondrial factors may be interacting with nuclear factors in a complex regulatory system.