High-performance liquid chromatography of quinidine in plasma, with use of a microparticulate silica column.
- 1 December 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 24 (12), 2166-2168
- https://doi.org/10.1093/clinchem/24.12.2166
Abstract
We describe a routine method for determining plasma concentrations of quinidine by liquid chromatography. The procedure requires 1.0 ml of plasma (or serum) and involves internal standard addition, extraction with ether, and separation on a column of microparticulate silica. Day-to-day CV (15 days) was less than 5% and no deterioration in column performance has been observed during 12 months. Comparison with a fluorometric procedure gave a correlation coefficient of 0.995.This publication has 8 references indexed in Scilit:
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