Telomeric association of chromosomes in B-cell lymphoid leukemia
- 1 September 1984
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 67 (4), 385-390
- https://doi.org/10.1007/bf00291396
Abstract
About 20% of leukemic bone marrow cells from each of two patients with B-cell lymphoid leukemias showed apparent translocations which appeared to be the result of telomeric association. In one patient, whole chromosomes were associated telomere to telomere in pairs; in the other patient, telomeres of whole chromosomes were associated with breakpoints located close to the proximal or distal ends of the heterochromatic band 1q12. Repeated base sequences, particularly (CA)n sequences, are believed to be the basis of telomere pairing, and likewise repeated base sequences of heterochromatin may explain the association of 1qh and telomeres. Telomeric association may be considered as a potential origin of new stable cytogenetic combinations that have a role in oncogene transposition and tumor etiology.This publication has 44 references indexed in Scilit:
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