Histamine2-Receptor Antagonists

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Abstract
THIS article reviews the clinical pharmacology of histamine2-receptor antagonist drugs (H2 blockers) and their usefulness in the treatment and prevention of acid-peptic disorders — namely, peptic ulcer disease, Zollinger—Ellison syndrome, gastroesophageal reflux disease, and acute stress ulcers and erosions. Erosive gastritis and erosive duodenitis are often considered acid-peptic diseases, but because they overlap with peptic ulcer disease they are not considered as separate entities in this review. Non-ulcer dyspepsia is not included as an acid-peptic disorder since it does not appear to respond to therapy with H2 blockers or antacids.1 H2 blockers are quite effective . . .