Evidence for a role for DNA polymerase β in mammalian meiosis
- 18 February 1997
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 94 (4), 1327-1331
- https://doi.org/10.1073/pnas.94.4.1327
Abstract
DNA polymerase beta (pol beta) is an enzyme possessing both polymerase and deoxyribose phophatase activities. Although pol beta is not believed to participate in the replication of genomic DNA, several studies have indicated a role for pol beta in DNA repair. The high level of expression of pol beta in mouse and rat testes raises the possibility that pol beta participates in mammalian meiosis. Using antibody localization, we detect foci that stain with pol beta antisera at discrete sites along homologous chromosomes as they synapse and progress through prophase of meiosis I. These data suggest that pol beta participates in meiotic events associated with synapsis and recombination.Keywords
This publication has 44 references indexed in Scilit:
- Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing overNature Genetics, 1996
- DNA Polymerases α and β Are Required for DNA Repair in an Efficient Nuclear Extract from Xenopus OocytesPublished by Elsevier ,1996
- Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosisCell, 1995
- Localization of RecA-like recombination proteins on chromosomes of the lily at various meiotic stages.Genes & Development, 1995
- DNA Polymerase β and DNA Synthesis in Xenopus Oocytes and in a Nuclear ExtractScience, 1992
- Chromsome synapsis and genetic recombination: their roles in meiotic chromsome segregationTrends in Genetics, 1990
- Changes in the DNA polymerase β gene expression during development of lung, brain, and testis suggest an involvement of the enzyme in DNA recombinationExperimental Cell Research, 1990
- Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding proteinGene, 1988
- Synaptonemal complex antigen location and conservation.The Journal of cell biology, 1987
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970