Metabolism of chimyl alcohol and phosphatidyl ethanolamine in the rat brain

Abstract
Following intracerebral injection of14C-phosphatidylethanolamine and3H-chimyl alcohol into 18 day old rats, the ethanolamine phosphoglycerides were isolated and analyzed. The14C and3H activities in the dimethyl acetals derived from alkenyl acyl ethanolamine phosphoglycerides and in the glyceryl ethers derived from the alkyl acyl ethanolamine phosphoglycerides were measured. The absence of14C in the dimethyl acetals indicates that phosphatidyl ethanolamine is not transformed into phosphatidal ethanolamine under these circumstances. The increase with time of the3H content of the glyceryl ethers and dimethyl acetals indicates that chimyl alcohol was a precursor of both types of phospholipids.