Taxol: Quantitative Internuclear Proton-Proton Distances in CDCl3 Solution from nOe Data: 2D NMR Roesy Buildup Rates at 500 MHz

Abstract

Quantitative nmr internuclear proton-proton distance measurements obtained by observation of the initial buildup rates of nOe's in 2D ROESY spectra of taxol [1] in CDCl3 are reported. A comparison to the X-ray crystal structure of taxotere [2] is made, and the results are discussed in terms of previous studies of structure-activity relationships.