EPSTEIN-BARR VIRUS
Open Access
- 1 January 1973
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 137 (1), 140-147
- https://doi.org/10.1084/jem.137.1.140
Abstract
Epstein-Barr virus (EBV)-transformed autologous lymphoblasts were repeatedly inoculated into three squirrel monkeys. Each animal developed the heterophile antibodies of infectious mononucleosis and EBV-specific antibodies. After serologic responses had disappeared or markedly declined, the animals were challenged with either whole cells, cell filtrate, or cell ghosts. Animals challenged with living cells and cell ghosts developed agglutinin responses; the recipient of filtrate did not. The results suggest that EBV induces the appearance of the infectious mononucleosis heterophile antigen on the transformed cell membrane.Keywords
This publication has 11 references indexed in Scilit:
- Infectious Mononucleosis: Appearance of Neutralizing Antibody to Epstein-Barr Virus Measured by Inhibition of Formation of Lymphoblastoid Cell LinesThe Journal of Infectious Diseases, 1972
- Epstein-Barr Virus: Transformation, Cytopathic Changes, and Viral Antigens in Squirrel Monkey and Marmoset LeukocytesProceedings of the National Academy of Sciences, 1972
- Transformation of Human Leucocytes by Throat Washing from Infectious Mononucleosis PatientsNature, 1971
- Malignant potential of a cell line isolated from the peripheral blood in infectious mononucleosisCancer, 1971
- Attempts to Transmit Infectious Mononucleosis to Rhesus Monkeys and Marmosets and to Isolate Herpes-Like VirusExperimental Biology and Medicine, 1969
- Seroepidemiologic Studies of Infectious Mononucleosis with Eb VirusNew England Journal of Medicine, 1968
- Infectious Mononucleosis: Complement-Fixing Antibodies to Herpes-Like Virus Associated with Burkitt LymphomaScience, 1968
- Infectious mononucleosis. Clinical manifestations in relation to EB virus antibodiesPublished by American Medical Association (AMA) ,1968
- Relation of Burkitt's tumor-associated herpes-ytpe virus to infectious mononucleosis.Proceedings of the National Academy of Sciences, 1968