Experiments on the mode of action of hexyl resorcinol as an anthelmintic

Abstract

1. Hexyl resorcinol penetrates readily into Ascaris lumbricoides var. suis through the cuticle.2. The rate of penetration is roughly proportional to the concentration of the drug in the medium, and is not significantly affected by changes of pH. or oxygen tension and the presence of a number of other substances, including other drugs and certain nutrient substances.3. The rate of penetration is greatly decreased by gastric mucin and certain concentrations of bile salts and soaps.4. The rate of penetration of the drug is increased by certain concentrations of sodium oleate.