Ceftriaxone in the treatment of ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.
- 1 October 1982
- journal article
- research article
- Published by BMJ in Sexually Transmitted Infections
- Vol. 58 (5), 314-316
- https://doi.org/10.1136/sti.58.5.314
Abstract
Ceftriaxone, a 3rd generation cephalosporin, was used in a single i.m. dose with oral probenecid to treat 124 men with infections due to non-penicillinase-producing N. gonorrhoeae (non-PPNG) and 64 men with infections due to PPNG. Three different doses of ceftriaxone were used: 125 mg, 62.5 mg and 32.5 mg. The cure rate for all PPNG infections with the different doses was 100%. The cure rate for the non-PPNG infections with ceftriaxone 125 mg was 100%; those for non-PPNG infections treated with ceftriaxone 62.5 mg and 32.5 mg were 96.2% and 97.3%, respectively. The 160 strains of non-PPNG and 60 strains of PPNG isolated were all susceptible to ceftriaxone with minimum inhibitory concentrations of 0.008 .mu.g/ml. These results are compared with those using kanamycin 2 g. Ceftriaxone is a safe and effective treatment for PPNG and non-PPNG infections.This publication has 6 references indexed in Scilit:
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