Subacute encephalitis and hydrocephalus in hamsters caused by measles virus from persistently infected cell cultures
- 1 January 1978
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 2 (4), 305-317
- https://doi.org/10.1002/jmv.1890020404
Abstract
Newborn hamsters were inoculated intracerebrally with measles virus materials from Lu 106 and Vero carrier cell lines. Extracellular and cell‐associated materials from cultures incubated at 37°C and at 33°C were used. The lower temperature allows accentuated virus replication. No animals contracted acute encephalitis, but 8 animals developed advanced neurological disease (unsteady gait, serial myoclonic jerks, hypoactivity) 79 to 212 days after injection. Seven out of these 8 animals belonged to a group of 50 animals, which had been inoculated with cell‐associated material from cultures incubated at 33°C. Viral antigen and nucleocapsids were found in neurons and glial cells from diseased animals, which showed degenerative changes and inflammation, particularly in the mesencephalon. Some of these animals also had hydrocephalus, which, however, also occurred in many apparently healthy animals. Also this pathological alteration occurred most frequently (5 out of 11 animals examined 9–10 months after inoculation) in hamsters receiving cell‐associated material from carrier cultures incubated at 33°C. Possible mechanisms for the appearance of hydrocephalus are discussed.Keywords
This publication has 23 references indexed in Scilit:
- Latent measles virus infection in Vero cells depending on a temperature-sensitive phenomenonArchiv für die gesamte Virusforschung, 1978
- The pathology of experimental obstructive hydrocephalusActa Neuropathologica, 1977
- Subacute sclerosing panencephalitis (SSPE) agent in hamsters: III. Induction of defective measles infection in hamster brainExperimental and Molecular Pathology, 1974
- Passage in Ferrets of Encephalitogenic Cell-Associated Measles Vims Isolated from Brain of a Patient with Subacute Sclerosing PanencephalitisThe Journal of Infectious Diseases, 1973
- Subacute Sclerosing PanencephalitisArchives of Neurology, 1972
- Experimental Subacute Sclerosing Panencephalitis in the Hamster: Correlation of Age with Chronic Inclusion-Cell EncephalitisThe Journal of Infectious Diseases, 1972
- Subacute Sclerosing Panencephalitis: A Review With 19 FiguresModern Aspects of Electrochemistry, 1972
- Neurotropism of Measles Virus Variants in HamstersThe Journal of Infectious Diseases, 1971
- Transmission of an Encephalitogenic Agent from Brains of Patients with Subacute Sclerosing Panencephalitis to FerretsNew England Journal of Medicine, 1968
- A carrier cell line of measles virus in Lu 106 cellsArchiv für die gesamte Virusforschung, 1967