Inhibition of Bacterial Adherence by Secretory Immunoglobulin A: A Mechanism of Antigen Disposal
- 25 August 1972
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 177 (4050), 697-699
- https://doi.org/10.1126/science.177.4050.697
Abstract
Preparations of secretory iminunoglobuilin A (S-IgA) isolated from human parotid fluid specifically inhibited the adherence of Streptococcus strains to epithelial cells. Since bacterial adherence is a prerequisite for colonization of mucous surfaces. S-IgA-mediated inhibition of adherence would limit bacterial colonization. This mechanism can explain how secretory immunoglobulins function in the disposal of bacterial antigens.Keywords
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