Indicator-Dilution Measurement of Cardiac Output with Dissolved Hydrogen
- 1 June 1968
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 22 (6), 841-853
- https://doi.org/10.1161/01.res.22.6.841
Abstract
Dissolved H 2 has been used as an indicator for measuring cardiac output by the techniques of constant-rate injection and sudden, single injection indicator dilution. Because of its low solubility, H 2 is eliminated essentially quantitatively in the lungs and recirculates negligibly. The constant-rate injection technique involves the gas chromatographic measurement of pulmonary (or systemic) arterial H 2 concentration during an infusion of dissolved H 2 into a vena cava (or the left atrium). Measurements in anesthetized dogs agreed well with simultaneous measurements by dye dilution, direct Fick, and direct volumetric techniques. Measurements could be repeated several times a minute, and using a linearly responding platinum electrode, intravascular H 2 concentrations could be recorded continuously. In the sudden, single injection technique, dissolved H 2 was injected into a vena cava (or the left atrium) while monitoring pulmonary (or systemic) arterial H 2 concentration with a chromatographically calibrated platinum electrode. Measurements again agreed with simultaneous measurements by dye dilution, constant-rate injection of H 2 , and the direct volumetric technique. Hydrogen curves could be repeated rapidly and integrated instantaneously. Hydrogen appears to be a useful indicator for rapidly repeated determinations of cardiac output and for measurements of output in situations in which recirculation of conventional indicators limits their usefulness.Keywords
This publication has 19 references indexed in Scilit:
- Indicator-dilution methods in estimation of cardiac output in clinical shockThe American Journal of Cardiology, 1967
- Effects of ventilation-perfusion inequality on elimination of inert gasesRespiration Physiology, 1967
- Elimination of inert gas by the lungRespiration Physiology, 1967
- The use of the hydrogen electrode to measure tissue blood flowJournal of Surgical Research, 1965
- Continuously Recorded Changes of Thoracic Aortic Blood Flow in Man in Response to Leg Exercise in Supine PositionCirculation Research, 1965
- Measurement of Local Blood Flow with Hydrogen GasCirculation Research, 1964
- ESTIMATION OF RIGHT VENTRICULAR OUTPUT IN MAN USING RADIOACTIVE KRYPTON (Kr85)*JCI Insight, 1961
- ESTIMATION OF PULMONARY ARTERIOVENOUS SHUNT-FLOW USING INTRAVENOUS INJECTIONS OF T-1824 DYE AND KR85*JCI Insight, 1960
- STUDIES OF THE VENTILATION-PERFUSION RELATIONSHIPS IN THE LUNGS OF SUBJECTS WITH CHRONIC PULMONARY EMPHYSEMA, FOLLOWING A SINGLE INTRAVENOUS INJECTION OF RADIOACTIVE KRYPTON (Kr85). I. PRESENTATION AND VALIDATION OF A THEORETICAL MODEL *JCI Insight, 1960
- THE APPLICATION OF THE FICK PRINCIPLE TO THE MEASUREMENT OF PULMONARY BLOOD FLOWProceedings of the National Academy of Sciences, 1958