Time of gene expression in relation to centromere distance during the cell cycle of Saccharomyces cereviseae.

Abstract

The periodic synthesis of a number of enzymes, whose structural genes are centromere-linked, was examined during the cell cycle in yeast. No direct relationship was observed between the time of expression of the structural genes and their centromere distance. The data thus far are inconsistent with a bidirectional model with the centromere as the point of initiation of transcription, but consistent with a unidirectional model of transcription of the genome.