The characteristics of chemo-sensitive and chemo-resistant GC cell lines. A. Tumors derived from distant metastases were more resistant to chemotherapy. A 3-week 5-FU administration treatment was performed when the secondary model was established for 2 weeks and the tumor burden was then analysed. B-C. The protein expression of HMGA2, FOXL2, ITGA2, E2F1 and Rb in chemo-sensitive and chemo-resistant GC cell lines. **P<0.01. D. The mRNA levels of HMGA2, FOXL2, ITGA2, CDC2, CCNE1 and TK1 in chemo-resistant and chemo-sensitive GC cells. **P<0.01.