Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling inXenopusaxis formation
Open Access
- 15 November 2008
- journal article
- Published by The Company of Biologists in Development
- Vol. 135 (22), 3719-3729
- https://doi.org/10.1242/dev.029025
Abstract
Wnt signaling in development and adult tissue homeostasis requires tight regulation to prevent patterning abnormalities and tumor formation. Here, we show that the maternal Wnt antagonist Dkk1 downregulates both the canonical and non-canonical signaling that are required for the correct establishment of the axes of the Xenopus embryo. We find that the target Wnts of Dkk activity are maternal Wnt5a and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling. We determine that Wnt5a and Wnt11 form a previously unrecognized complex. This work suggests a new aspect of Wnt signaling: two Wnts acting in a complex together to regulate embryonic patterning.Keywords
This publication has 33 references indexed in Scilit:
- xDnmt1 regulates transcriptional silencing in pre-MBTXenopusembryos independently of its catalytic functionDevelopment, 2008
- Multiplicity of the interactions of Wnt proteins and their receptorsCellular Signalling, 2007
- Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/βcatenin and Wnt/PCP activities, through interaction with the Dally-like homolog KnypekGenes & Development, 2007
- Function and biological roles of the Dickkopf family of Wnt modulatorsOncogene, 2006
- Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membraneThe Journal of cell biology, 2006
- Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor ContextPLoS Biology, 2006
- Maternal Wnt11 Activates the Canonical Wnt Signaling Pathway Required for Axis Formation in Xenopus EmbryosCell, 2005
- Frizzled receptor dimerization is sufficient to activate the Wnt/β-catenin pathwayJournal of Cell Science, 2003
- Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulationNature, 2000
- The mechanism for increased protein synthesis during Xenopus oocyte maturationDevelopmental Biology, 1982