Molecular properties of the nerve growth factor secreted by L cells.
- 1 April 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (4), 1492-1496
- https://doi.org/10.1073/pnas.74.4.1492
Abstract
The molecular size and stability of the nerve growth factor (NGF) secreted in culture by L cells were studied by sedimentation and gel filtration chromatography. L cell NGF has a MW of 160,000. It contains as part of its structure a protein component that is biologically, immunologically and electrophoretically indistinguishable from the biologically active factor purified from mouse submandibular glands. Unlike pure gland NGF, L cell NGF is highly stable in solution, and this finding indicates that L cell NGF is a form of the factor different from that previously described.This publication has 18 references indexed in Scilit:
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