Ioglycamide (Biligram) studies in man—relation between plasma concentration and biliary excretion

Abstract

Plasma ioglycamide concentration was linearly related to the rate of i.v. infusion over a dose range of from 1-4 mg/kg per min. The relation between plasma and biliary concentration of ioglycamide was studied in 15 anicteric patients with a T-tube in situ. Peak biliary concentrations and excretory rates of ioglycamide were seen when the plasma concentration was > 1500 .mu.g/ml. The mean biliary transport maximum (Tm) for ioglycamide in man was 31.6 mg/min (range 22.0-40.4). Near optimal concentrations of I in the bile duct can be obtained during i.v. cholangiography if ioglycamide is infused for 1 h at a rate of about 4 mg/kg per min.