A Histomorphometric Analysis of the Effects of Fluoride on Experimental Ectopic Bone Formation in the Rat
- 1 June 1991
- journal article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 70 (6), 957-960
- https://doi.org/10.1177/00220345910700060901
Abstract
Ectopic bone formation was induced in 14 rats receiving 100 ppm fluoride in drinking water and in 14 control animals. Sections from ossicles removed after 14 and 20 days were sampled for stereological analysis. Bone volume density and bone volume were reduced in experimental animals on day 14 (p < 0.05). This difference was no longer present after 20 days. On day 20, surface density and areas of formative surfaces were increased in the fluoride group (pin vivo.Keywords
This publication has 16 references indexed in Scilit:
- A proposed mechanism of the mitogenic action of fluoride on bone cells: Inhibition of the activity of an osteoblastic acid phosphataseMetabolism, 1989
- The effects of fluoride on bone and implant histomorphometry in growing ratsJournal of Bone and Mineral Research, 1989
- Effect of sodium fluoride, calcium, phosphate, and vitamin D2 on trabecular bone balance and remodeling in osteoporoticsBone, 1985
- Experimental Osteo-fluorosis in the Domestic Pig: A Histomorphometric Study of Vertebral Trabecular BoneJournal of Dental Research, 1984
- Fluoride Directly Stimulates Proliferation and Alkaline Phosphatase Activity of Bone-Forming CellsScience, 1983
- Estimation of the three-dimensional wall thickness of completed remodeling sites in iliac trabecular boneMetabolic Bone Disease and Related Research, 1982
- An elementary introduction to stereology (quantitative microscopy)Journal of Anatomy, 1980
- Collagenous bone matrix-induced endochondral ossification hemopoiesis.The Journal of cell biology, 1976
- Effect of combined therapy with sodium fluoride, vitamin D and calcium in osteoporosisThe American Journal of Medicine, 1972
- Effect of Sodium Fluoride on Calcium Metabolism of Human BeingsNature, 1961