The Multiple Functions of Hemoglobin
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in Critical Reviews in Biochemistry and Molecular Biology
- Vol. 30 (3), 165-196
- https://doi.org/10.3109/10409239509085142
Abstract
The aim of this review is to focus and discuss several parallel biological functions of hemoglobin besides its basic function of oxygen transport. In light of the information present in the literature the following possible physiological roles of hemoglobin are discussed: (1) hemoglobin as molecular heat transducer through its oxygenation-deoxygenation cycle, (2) hemoglobin as modulator of erythrocyte metabolism, (3) hemoglobin oxidation as an onset of erythrocyte senescence, (4) hemoglobin and its implication in genetic resistance to malaria, (5) enzymatic activities of hemoglobin and interactions with drugs, and (6) hemoglobin as source of physiological active catabolites.Keywords
This publication has 98 references indexed in Scilit:
- Physiological Relevance of the Overall ΔH of Oxygen Binding to Fetal Human HemoglobinJournal of Molecular Biology, 1993
- Isolation and characterization of two opioid peptides from a bovine hemoglobin peptic hydrolysateBiochemical and Biophysical Research Communications, 1992
- High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-State haemoglobins: T(α-oxy)haemoglobin and T(met)haemoglobinJournal of Molecular Biology, 1992
- Interactions of glycolytic enzymes with erythrocyte membranesBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1990
- Carbon monoxide effects on calcium levels in vascular smooth muscleLife Sciences, 1988
- Differential monooxygenase-like activity of fetal and adult erythrocytesBiochemical and Biophysical Research Communications, 1980
- Identification of residues contributing to the Bohr effect of human haemoglobinJournal of Molecular Biology, 1980
- Binding of rabbit muscle aldolase to band 3, the predominant polypeptide of the human erythrocyte membraneBiochemistry, 1976
- Formation of Superoxide in the Autoxidation of the Isolated alpha and beta Chains of Human Hemoglobin and Its Involvement in Hemichrome PrecipitationEuropean Journal of Biochemistry, 1975
- On the nature of allosteric transitions: A plausible modelJournal of Molecular Biology, 1965