Characteristic Electrophoretic Patterns in Hemophilia and Idiopathic Thrombocytopenia.

Abstract

A typical electrophoretic pattern was observed consistently in 5 cases of hemophilia and in 8 cases of idiopathic thrombocytopenic purpura. This pattern is characterized by: (a) appearance of an unusual peak in the group of the [alpha]-globulins ([alpha]x) with a motility ranging between 4.30 and 4.60 x 10-5 sq. cm./volt sec. in veronal-citrate buffer, pH 8.6, ionic strength 0.1; (b) complete disappearance of the usual [alpha]2 and [alpha]3-globulin peaks with motiiity between 3.75 and 4.25 x 10-5 sq. cm./volt sec. A similar anomaly was observed in some cases of anaphylactoid purpura and secondary thrombocytopenia. It was not encountered in 164 other cases studied thus far. The described anomaly persisted in hemophilic patients even after normalization of their clotting time by means of fresh blood transfusions and in patients with thrombocytopenic purpura after successful remission of the disease induced by splenectomy or spontaneous.