Crohn's disease and vitamin B12 metabolism

Abstract

The concentrations of vitamin B₁₂, its analogs, and the haptocorrin and transcobalamin carriers in 21 patients suffering from Crohn's disease and a group of controls (20 adults) were measured. There were no significant differences in the mean values for vitamin B₁₂, total corrinoids (vitamin B₁₂ + analogs), or vitamin B₁₂ or total corrinoids bound to haptocorrin or transcobalamin of the Crohn's and control patients. There was a significant increase in the binding capacity of transcobalamin in the Crohn's patients compared to the controls (P12 status, homocysteine and methylmalonic acid, showed an increase (P12 status.