Perioperative Blood Transfusions and Delayed Wound Healing After Hip Replacement Surgery: Effects on Duration of Hospitalization
- 1 May 2005
- journal article
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 100 (5), 1416-1421
- https://doi.org/10.1213/01.ane.0000150610.44631.9d
Abstract
Patients who receive allogeneic blood transfusions after orthopedic surgery have a longer duration of hospitalization, and this cannot be explained by a more frequent incidence of infections in transfused patients. To determine whether transfusion of allogeneic blood interferes with wound healing and therefore increases the duration of hospitalization, we performed an observational study in 444 consecutive patients scheduled for elective primary hip surgery. Transfusion, wound, and infection variables were collected at five time points during treatment. Of the 444 consecutive patients studied, 92 received blood transfusions during their perioperative course. Thirty-one percent of transfused patients developed wound-healing disturbances versus 18% of the nontransfused group (P < 0.05); allogeneic blood transfusion was the only significant predictor for development of minor wound-healing disturbances. Duration of hospitalization was prolonged in transfused patients (12.3 versus 9.8 days) and could be predicted by 4 significant variables: requirement for blood transfusion (adds 2.7 +/- 0.5 days), presence of wound-healing disturbances (adds 1.3 +/- 0.5 days), duration of surgery (adds 0.2 +/- 0.1 days/10 min), and patient's age (adds 0.9 +/- 0.2 days/10 yr). These data suggest that allogeneic blood transfusion is associated with an increased incidence of wound-healing disturbances and that prevention of allogeneic blood transfusion may be relevant in limiting the duration of admission after elective orthopedic surgery.Keywords
This publication has 19 references indexed in Scilit:
- Leukocyte-depletion of blood components does not significantly reduce the risk of infectious complicationsInternational Journal of Colorectal Disease, 2001
- Randomized trial comparing packed red cell blood transfusion with and without leukocyte depletion for gastrointestinal surgeryThe American Journal of Surgery, 1998
- Randomised comparison of leucocyte-depleted versus buffy-coat-poor blood transfusion and complications after colorectal surgeryThe Lancet, 1996
- Perioperative blood transfusion and cancer recurrence: meta‐analysis for explanationTransfusion, 1995
- Randomised controlled trial comparing transfusion of leucocyte-depleted or buffy-coat-depleted blood in surgery for colorectal cancerThe Lancet, 1994
- Blood transfusion and postoperative septic complicationsTransfusion, 1994
- Autologous blood and infections after colorectal surgeryThe Lancet, 1994
- Beneficial effect of autologous blood transfusion on infectious complications after colorectal cancer surgeryThe Lancet, 1993
- Allogeneic leukocytes but not therapeutic blood elements induce reactivation and dissemination of latent human immunodeficiency virus type 1 infection: implications for transfusion support of infected patientsBlood, 1992
- Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgeryBritish Journal of Surgery, 1992