OBSERVATIONS ON TOLERANCE AND RATE OF UTILIZATION OF GLUCOSE IN A SERIES OF INDIVIDUALS EXHIBITING VARIOUS DEGREES OF DIABETES MELLITUS

Abstract

Third Paper Hamman and Janney have both recently reviewed the literature on this phase of the problem; accordingly, we shall only comment on some of the more important investigations. Hopkins¹ points out that in health a moderate rise up to 0.14 or 0.15 per cent. in blood sugar follows the ingestion of 100 gm. of glucose. The curve reaches its peak in from one half to two hours, then quickly subsides. In disturbed carbohydrate metabolism, a normal sugar concentration may be associated with a most pronounced alimentary hyperglycemia. In diabetes, the hyperglycemia is very pronounced; the peak is reached in from one half to three hours and is prolonged. According to Taylor and Hutton² in the majority of healthy males there is no limit to the assimilation of glucose. Glycosuria does not follow the largest possible ingestion of glucose. Wilder and Sansum³ in an elaborate study of the subject raise