IN VIVODISTRIBUTION OF SOME 17-HYDROXYCORTICOSTEROIDS BETWEEN THE PLASMA AND RED BLOOD CELLS OF MAN*

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Abstract
Various corticosteroids (cortisol, tetrahydrocortisol or tetrahydrocortisone intravenously, 1 mg per Kg of body weight; 4-C14-cortisol intravenously, 1 microcurie; cortisol or cortisone acetate orally, 100 mg) were administered to normal adult subjects. Blood samples were obtained at specific intervals following administration of steroid. 17-Hydroxycorticosteroid (17-OH-CS) extracts of red cells and plasma were prepared. In all cases, a significant fraction of the free 17-OH-CS of the various blood samples was associated with the red cells (average, 25.1 percent; range. 17.7 to 36.5 percent), whereas the total amount of the 17-OH-CS glucuronides was found in the plasma.