Synthesis of a Protected Phosphoamino Acid, N?-tert-Butyloxycarbonyl-O-Diethylphosphoro-L-Serine

Abstract

Phosphoproteins are known to play metabolic and structural roles in many biological processes. In such proteins, serine is the most commonly phosphorylated amino acid and is usually flanked by a cluster of acidic or basic residues. In our studies of the structure and reactivity of the phosphorylated segments of the caseins, we have been concerned with the development of a synthetic methodology suitable for the rapid synthesis in gram quantities of phosphopeptides.