THE HIV-1 REV PROTEIN
- 1 October 1998
- journal article
- review article
- Published by Annual Reviews in Annual Review of Microbiology
- Vol. 52 (1), 491-532
- https://doi.org/10.1146/annurev.micro.52.1.491
Abstract
▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles between the nucleus and the cytoplasm and harbors both a nuclear localization signal and a nuclear export signal. These essential peptide motifs have now been shown to function by accessing cellular signal-mediated pathways for nuclear import and nuclear export. HIV-1 Rev therefore represents an excellent system with which to study aspects of transport across the nuclear envelope.Keywords
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