Studies on Phenylketonuria IV. Serum Proteins in Phenylketonuria.

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Abstract
The greatly increased blood levels of phenylalanine that occur in phenylketonuria do not cause a significant quantitative alteration of the serum protein pattern from normal. Occasional serums of children with phenylketonuria contain abnormal beta-globulins. Upon feeding phenylalanine-low diets, these abnormalities disappear and the blood phenylalanine is lowered to the normal range. There appears to be no correlation between the presence of the abnormal beta-globulins and the degree of mental impairment. The abnormal globulins are probably manifestations of slight liver dysfunction.