Cognitive Dysfunction in Mice Infected withPlasmodium bergheiStrain ANKA
Open Access
- 1 June 2008
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 197 (11), 1621-1627
- https://doi.org/10.1086/587908
Abstract
Cerebral malaria complicated by cognitive sequelae is a major cause of morbidity in humans infected with Plasmodium falciparum. To model cognitive function after malaria, we created a rodent model of cerebral malaria by infecting C57BL/6 mice with Plasmodium berghei strainANKA.After 7 days, an object-recognition test of working memory revealed a significant impairment in the visual memory of infected mice. This impairment was observed in the absence of confounding effects of infection. The cognitive dysfunction correlated with hemorrhage and inflammation. Furthermore, microglial activity and morphological changes detected throughout the brains of infected mice were absent from the brains of control mice, and this correlated with the measured cognitive defects. Similar testing methods in human studies could help identify subjects at risk for an adverse cognitive outcome. This murine model should facilitate the study of adjunctive methods to ameliorate adverse neurological outcomes in cerebral malaria.Keywords
This publication has 51 references indexed in Scilit:
- Cognitive Impairment After Cerebral Malaria in Children: A Prospective StudyPediatrics, 2007
- Interleukin-6 Facilitates Lipopolysaccharide-Induced Disruption in Working Memory and Expression of Other Proinflammatory Cytokines in Hippocampal Neuronal Cell LayersJournal of Neuroscience, 2006
- Cytokine, Sickness Behavior, and DepressionNeurologic Clinics, 2006
- Reduced cerebral blood flow and N-acetyl aspartate in a murine model of cerebral malariaZeitschrift Fur Parasitenkunde-Parasitology Research, 2005
- Reactive Changes of Retinal Microglia during Fatal Murine Cerebral Malaria: Effects of Dexamethasone and Experimental Permeabilization of the Blood-Brain BarrierThe American Journal of Pathology, 2000
- Microglia: a sensor for pathological events in the CNSTrends in Neurosciences, 1996
- Impaired object recognition memory in rats following ischemia-induced damage to the hippocampus.Behavioral Neuroscience, 1993
- A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memoryBehavioural Brain Research, 1992
- Malaria presenting as atypical depressionThe British Journal of Psychiatry, 1990
- Cerebral malaria in inbred mice. I. A new model and its pathologyTransactions of the Royal Society of Tropical Medicine and Hygiene, 1982