Papillomatosis in the Forestomach of the Rat and its Bearing on the Work of Fibiger

Abstract

This paper deals with the conditions determining the onset of an extensive benign hyperplasia of the squamous epithelium lining the forestomach of the rat, associated with an extraordinarily massive hyperkeratosis. To the naked eye this lesion appears as numerous papillomata or warty excrescences occupying a large portion of the forestomach. The existence of a moderate degree of hyperplasia of the squamous epithelium without the appearance of warts or papillomata, or with but a few isolated growths of this kind, is not included in the considerations dealt with in this paper. The author's contribution to this subject consists in two series of experiments carried out at an interval of ten years under apparently identical conditions, which gave entirely discordant results.