The Effect of Somatostatin on Bombesin-Stimulated Serum Gastrin and Gastric Acid Secretion in Man
- 31 December 1980
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 21 (4), 193-197
- https://doi.org/10.1159/000198562
Abstract
The effect of intravenous somatostatin on bombesin-stimulated serum gastrin and gastric acid secretion was studied in 5 healthy subjects. Somatostatin, 100 ng/kg/min, significantly inhibited serum gastrin and gastric acid responses to infusion of bombesin-tetradecapeptide in a dose of 2.5 ng/kg/min. Inhibition of gastrin release could not fully account for the inhibition of gastric acid secretion. Since both bombesin and somatostatin are present in the antrum of man, interrelations between these peptides might be involved in gastrin release from the antrum.Keywords
This publication has 8 references indexed in Scilit:
- Effects of atropine and bethanechol on bombesin-stimulated release of pancreatic polypeptide and gastrin in dogGastroenterology, 1979
- Inhibition of Bombesin-Stimulated Gastric Acid Secretion by Secretin, Glucagon and Caerulein in Patients with Duodenal UlcerDigestion, 1979
- Pancreatic Polypeptide Responses to a Meal and to Intraduodenal Amino Acids and Sodium Oleate*Endocrinology, 1978
- The Effect of Somatostatin on Pentagastrin-stimulated Gastric Secretion and on Plasma Gastrin in ManScandinavian Journal of Gastroenterology, 1977
- Effect of somatostatin on meal-induced gastric secretion in duodenal ulcer patientsDigestive Diseases and Sciences, 1977
- INHIBITION OF CHOLECYSTOKININ-PANCREOZYMIN RELEASE BY SOMATOSTATINThe Lancet, 1977
- Inhibition by Somatostatin of Gastrin Release and Gastric Acid Responses to Meals and to Pentagastrin in ManScandinavian Journal of Gastroenterology, 1977
- Comparative study of the value of the calcium, secretin, and meal stimulated increase in serum gastrin to the diagnosis of the Zollinger-Ellison syndrome.Gut, 1977