Chromosome Studies on Testicular Tissue Cultures and Blood Leukocytes of a Male Previously Reported to Have No Y Chromosome

Abstract

IN 1961 Oikawa and Blizzard¹ described an eleven-year-old phenotypic male with bilateral undescended testes, clinical features of Turner's syndrome, a positive buccal smear and absence of a Y chromosome in bone-marrow cells. There was no apparent explanation of the failure of this patient to conform to the theory that the Y chromosome carries male-determining genes.Testicular tissue in the absence of a demonstrable Y chromosome has been reported in true hermaphrodites. Rosenberg et al.² and Solomon and Green³ proposed that the usual finding of an XX chromosome pattern in true hermaphrodites suggests a genetic disturbance in these cases. It is . . .