Faecal Blood Loss during Treatment with Ibufenac, a New Analgesic Drug

Abstract

Measurements of alimentary blood loss during treatment with Ibufenac, a new analgesic drug, have been made by the Cr51 technique Ten patients with no known gastro-intestinal lesion received Ibufenac for 7 days and in 7 of them no significant alimentary bleeding occurred; 1 patient, who had thrombocytopenia, showed slight blood loss of similar degree during the administration of both Ibufenac and paracetamol (acetaminophen); in the other 2 cases blood loss, of very slight degree occurred during Ibufenac therapy. Fecal blood loss was considerably less with Ibufenac than with aspirin. One other patient, who had duodenal ulceration and who was actively bleeding at the start of the study, showed much less blood loss with Ibufenac than with aspirin.