Further investigations on the effect of denervation and pH on the conductance change at the neuromuscular junction of the frog
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 364 (1), 53-58
- https://doi.org/10.1007/bf01062911
Abstract
Currents induced by acetylcholine application at the voltage-clamped frog end-plate, were measured over a large range of membrane potentials. Due to a non-linearity of the current-voltage curve, the directly-measured reversal potential may be quite different from the value classically determined by extrapolation (linear regression) of the measurements made at potentials below spike threshold. Denervation and changes of external pH were found to alter the shape of the current-voltage relation, but not the directly-measured reversal potential. These effects are tentatively explained on the basis of changes in the ratio: time-to-peak for [ACh] reaching the receptors/mean life-time of the open synaptic channels. Possible changes in cooperativity are also considered.This publication has 36 references indexed in Scilit:
- Current-voltage relation and reversal potential at junctional and extrajunctional ACh-receptors of the frog neuromuscular junctionPflügers Archiv - European Journal of Physiology, 1976
- The amplitude and the time course of the end‐plate current at various pH levels in the frog sartorius muscle.The Journal of Physiology, 1975
- Voltage-dependence of drug-induced conductance in frog neuromuscular junction.Proceedings of the National Academy of Sciences, 1975
- Density and dose-response curve of acetylcholine receptors in frog neuromuscular junctionNature, 1975
- Voltage clamp analysis of acetylcholine produced end‐plate current fluctuations at frog neuromuscular junctionThe Journal of Physiology, 1973
- An analysis of acetylcholine responses of junctional and extrajunctional receptors of frog muscle fibres. With an AppendixThe Journal of Physiology, 1971
- Potassium Exchange and Afterpotentials in Frog Sartorius Muscles Treated with GlycerolThe Journal of general physiology, 1970
- The effect of procaine on neuromuscular transmissionThe Journal of Physiology, 1970
- The effect of atropine and curarine on the time course of the end-plate potential in frog sartorius muscleInternational Journal of Neuropharmacology, 1968
- The Influence of pH on the Enzymic Hydrolysis of Acetylcholine.Acta Chemica Scandinavica, 1952