Identification of a specific olfactory receptor for 2-isobutyl-3-methoxypyrazine

Abstract
2-Isobutyl-3-methoxypyrazine, a potent bell-pepper odorant, binds to cow olfactory mucosa homogenate. The receptor is saturable in the micromolar range and is competitively inhibited by other bell-pepper odorants, but not by other pyrazines of different odors. Other tissues do not bind 2-isobutyl-3-methoxypyrazine to a significant extent. This receptor may be involved in odor discrimination.